Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease
Zhipei Sang, Qing Song, Zhongcheng Cao, Yong Deng, Li Zhang
Abstract
was a promising multi-target-directed ligand for treating AD.
Topics & Concepts
ChalconeDonepezilHybridPharmacologyDiseaseChemistryMedicineDementiaStereochemistryBiologyInternal medicineBotanyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity