Two new isoquinoline alkaloids from <i>Hypecoum leptocarpum</i> Hook. f. et Thoms
Huaixiu Wen, Xiang Yuan, Caixia Li, Jun Li, Huilan Yue
Abstract
Two new isoquinoline alkaloids, hypecocarpinine (1) and leptocaramine (2) along with five known ones including leptopidine (3), corydamine (4), protopine (5), dihydroprotopine (6) and oxohydrastinine (7), were isolated from Hypecoum leptocarpum Hook. f. et Thoms. Structures of the compounds were elucidated using spectroscopic methods, including UV, IR, HR-ESI-MS, 1 D and 2 D NMR. The cytotoxic activities of these compounds were evaluated using MTT assay. The results showed that compounds 2, 4, and 7 have moderate cytotoxicity against human lung cancer (A549) and human gastric carcinoma (MGC-803) cell lines.
Topics & Concepts
IsoquinolineProtopineCytotoxicityChemistryStereochemistryHookMTT assayAlkaloidIn vitroBiochemistryEngineeringStructural engineeringBerberine and alkaloids researchSynthesis and Biological ActivityZiziphus Jujuba Studies and Applications