SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity
Chiao-Yin Lim, Huan-Ting Lin, Caroline Kumsta, Tzu‐Chiao Lu, Feng‐Yung Wang, Yun-Hsuan Kang, Malene Hansen, Tsui‐Ting Ching, Ao‐Lin Hsu
Abstract
ChIP: chromatin immunoprecipitation; ChIP-seq: chromatin immuno precipitation-sequencing; COMPASS: complex of proteins associated with Set1; DR: dietary restriction; GO: gene ontology; SAM: S-adenosyl methionine; SAMS-1: S-adenosyl methionine synthetase-1; TSS: transcription start site; WT: wild-type.
Topics & Concepts
BiologyTFEBChromatin immunoprecipitationAutophagyTranscription factorHistoneChromatinEpigeneticsCell biologyGeneticsHistone methyltransferaseHistone methylationLongevityTranscription (linguistics)GenePromoterDNA methylationGene expressionLinguisticsPhilosophyApoptosisEpigenetics and DNA MethylationAutophagy in Disease and Therapy