Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics
Hao Cui, Qianqian Hong, Ran Wei, Hongmei Li, Chunyang Wan, Xin Chen, Shuang Zhao, Bu Haizhi, Bingxu Zhang, Dexiao Yang, Tao Lu, Yadong Chen, Yong Zhu
Topics & Concepts
Metabolic stabilityBioavailabilityPharmacokineticsChemistryPharmacologyLymphomaDrugEpigeneticsVorinostatHistone deacetylaseToxicityIn vitroHistoneBiochemistryMedicineInternal medicineGeneOrganic chemistryHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis