Mitochonic acid 5 rescues cardiomyocytes from doxorubicin-induced toxicity via repressing the TNF-α/NF-κB/NLRP3-mediated pyroptosis
Wenliang Zha, Qian Zhao, Ye Xiao, Yuanyuan Gan, Junjun Wei, Mengqi Yu, Yanmei Xu, Qiongyao Xu, Shi Wu, Wei Yu, Wei Yu
Topics & Concepts
CardiotoxicityPharmacologyDoxorubicinPyroptosisOxidative stressInflammationBiologyReactive oxygen speciesTumor necrosis factor alphaApoptosisCancer researchMedicineProgrammed cell deathToxicityImmunologyInternal medicineBiochemistryChemotherapyChemotherapy-induced cardiotoxicity and mitigationInflammasome and immune disordersCardiac Fibrosis and Remodeling