Potent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapy
Mohamed S. Nafie, M. Ali, Moayad Abdullah Alwehaibi, Abdulmajeed Abdullah Alayyaf, Muhanna K. Al‐Muhanna, Naif S. Almuqati, Abdullah A. Alghamdi, Matti Haukka, Shamoon Tariq, Zaheer Ul‐Haq, Assem Barakat
Abstract
= 1.49 nM, 94.5%). Furthermore, compound 4a-treatment induced increased apoptosis by 6.6-fold, as the effective cell death mechanism. Overall, our study underscores the importance of multi-targeted approaches in developing effective anti-cancer agents.
Topics & Concepts
ConjugateChemistryCancer researchTriazoleLiver cancerCancer therapyPoly ADP ribose polymeraseApoptosisPARP inhibitorPharmacologyCancerCombinatorial chemistryBiochemistryMedicineInternal medicineEnzymeHepatocellular carcinomaOrganic chemistryMathematicsMathematical analysisPolymerasePARP inhibition in cancer therapyCancer therapeutics and mechanismsComputational Drug Discovery Methods