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Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M)

Mennatallah A. Shaheen, Ali A. El‐Emam, Nadia S. El‐Gohary

2020Bioorganic Chemistry28 citationsDOI

Topics & Concepts

ChemistryCytotoxicityIC50T790MCancer cellErlotinibApoptosisQuinolineKinaseCell culturePharmacologyCell cycle checkpointIn vitroCell cycleBiochemistryCancerEpidermal growth factor receptorBiologyReceptorGefitinibOrganic chemistryGeneticsLung Cancer Treatments and MutationsCancer therapeutics and mechanismsQuinazolinone synthesis and applications
Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M) | Litcius