Comparative Genomics of Streptococcus oralis Identifies Large Scale Homologous Recombination and a Genetic Variant Associated with Infection
Luke R. Joyce, Madison A. Youngblom, Harshini Cormaty, Evelyn Gartstein, Katie E. Barber, Ronda L. Akins, Caitlin S. Pepperell, Kelli L. Palmer
Abstract
The viridians group streptococci (VGS) are a large collection of closely related commensal streptococci, with many being opportunistic pathogens causing invasive diseases, such as bacteremia and infective endocarditis. Little is known about virulence determinants in these species, and there is a distinct lack of genomic information available for the VGS.
Topics & Concepts
Streptococcus oralisHomologous chromosomeGenomicsGeneticsBiologyHomologous recombinationComputational biologyEvolutionary biologyStreptococcusGenomeGeneBacteriaStreptococcal Infections and TreatmentsInfective Endocarditis Diagnosis and ManagementNeonatal and Maternal Infections