Oridonin acts as a novel senolytic by targeting glutathione <i>S</i>-transferases to activate the ROS-p38 signaling axis in senescent cells
Ying Zhang, Qianyu Zhang, Zheng Chu, Lin Chen, Jiayun Chen, Yang Yang, Huan Tang, Guangqing Cheng, Ang Ma, Ying Zhang, Chen Wang, Peng Gao, Fei Xia, Qiuyan Guo, Qiaoli Shi, Guang Han, Jigang Wang, Yinhua Zhu
Abstract
We have identified oridonin as a novel senolytic and revealed the mechanism of oridonin by covalently inhibiting a class of glutathione S-transferases (GSTs) to increase the ROS level, and activate p38 to induce apoptosis in senescent cells.
Topics & Concepts
GlutathioneCell biologyChemistryp38 mitogen-activated protein kinasesSignal transductionApoptosisMechanism (biology)Reactive oxygen speciesPhosphorylationCancer researchBiochemistryBiologyProtein kinase AEnzymeEpistemologyPhilosophyGlutathione Transferases and PolymorphismsGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stress