Fluoroquinolone versus Beta-Lactam Oral Step-Down Therapy for Uncomplicated Streptococcal Bloodstream Infections
Kellie Arensman, Maureen Shields, Maya Beganovic, Jessica L. Miller, Erik LaChance, Morgan Anderson, Jennifer Dela‐Pena
Abstract
Fluoroquinolones (FQs) are often preferred as oral step-down therapy for bloodstream infections (BSIs) due to favorable pharmacokinetic parameters; however, they are also associated with serious adverse events. The objective of this study was to compare clinical outcomes for patients who received an oral FQ versus an oral beta-lactam (BL) as step-down therapy for uncomplicated streptococcal BSIs. This multicenter, retrospective cohort study analyzed adult patients who completed therapy with an oral FQ or BL with at least one blood culture positive for a Streptococcus species from 1 January 2014 to 30 June 2019.
Topics & Concepts
MedicineInternal medicineBacteremiaAdverse effectRetrospective cohort studyBeta-lactamCombination therapyAntibacterial agentAntibioticsIntensive care medicineMicrobiologyBiologyStreptococcal Infections and TreatmentsBacterial Identification and Susceptibility TestingAntibiotics Pharmacokinetics and Efficacy