Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults
Shay Nemet, Daniel Elbirt, Ramon Cohen, Keren Mahlab‐Guri, Shira Bezalel‐Rosenberg, Ilan Asher, Aviv Talmon, Limor Rubin, Yaarit Ribak, Ruslan Sergienko, Udi Nussinovitch, Yuval Tal, Oded Shamriz
Abstract
Background: Very high serum IgE (≥1000 IU/mL) is reported in atopic disorders. However, data on its significance in nonallergic disorders are limited. Objective: We aimed to analyze the diagnostic value of very high IgE in adults. Methods: < .05). Results: < .001). Conclusions: Very high IgE level of ≥1000 IU/mL is associated with increased risks of CVD, IEI, and eosinophilic disorders. Physicians should consider further assessment for these conditions in nonallergic patients with very high IgE levels.
Topics & Concepts
MedicineImmunoglobulin EImmunologyAntibodyImmunodeficiency and Autoimmune DisordersUrticaria and Related ConditionsMonoclonal and Polyclonal Antibodies Research