Point Mutation or Overexpression of Aspergillus fumigatus <i>cyp51B,</i> Encoding Lanosterol 14α-Sterol Demethylase, Leads to Triazole Resistance
Mariana Handelman, Zohar Meir, Jennifer Scott, Yona Shadkchan, Wei Liu, Ronen Ben‐Ami, Jorge Amich, Nir Osherov
Abstract
Aspergillus fumigatus is the most common cause of invasive fungal mold infections in immunocompromised individuals. Current antifungal treatment relies heavily on the triazole antifungals which inhibit fungal Erg11/Cyp51 activity and subsequent ergosterol biosynthesis.
Topics & Concepts
Aspergillus fumigatusErgosterolBiologyMicrobiologyTriazoleMutationLanosterolVoriconazolePoint mutationPosaconazoleDrug resistanceAspergillusAspergillosisSterolAntifungalGeneGeneticsChemistryBiochemistryImmunologyCholesterolOrganic chemistryAntifungal resistance and susceptibilityFungal Biology and ApplicationsFungal Infections and Studies