Synthesis and biological evaluation of ruthenium polypyridine complexes with 18β-glycyrrhetinic acid as antibacterial agents against <i>Staphylococcus aureus</i>
Qin Zhang, Yanshi Xiong, Jianxin Cheng, Yanhui Tan, Xiangwen Liao, Jintao Wang
Abstract
. Moreover, the results of histopathological research were consistent with the results of the hemolysis test, indicating that the Ru2 complex was almost non-toxic. Thus, it was demonstrated that the polypyridine ruthenium complexes modified with glycyrrhetinic acid (GA) are a promising strategy for developing interesting antibacterial agents.
Topics & Concepts
RutheniumStaphylococcus aureusChemistryHemolysisAntimicrobialAntibacterial activityCytotoxicityChloramphenicolStereochemistryMinimum inhibitory concentrationMode of actionAntibioticsCombinatorial chemistryIn vitroBiochemistryBacteriaOrganic chemistryBiologyImmunologyCatalysisGeneticsPharmacological Effects of Natural CompoundsMycobacterium research and diagnosisNatural Compounds in Disease Treatment