TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension
Fu‐Chiang Yeh, Chien-Nien Chen, Chong-Yang Xie, Nicoleta Baxan, Lin Zhao, Ali Ashek, Farah Sabrin, Allan Lawrie, Martin R. Wilkins, Lan Zhao
Abstract
<h3>Tweetable abstract</h3> <b>This study introduced a combination of autoimmune stimuli (TLR-7/8 agonist) and endothelial injury (Sugen) and established a novel rat model representing immune–vascular pathological events mimicking human PAH associated with autoimmune disorders</b>https://bit.ly/3P3H5V0
Topics & Concepts
TLR7PathologicalAgonistImmune systemMedicinePulmonary hypertensionImmunologyReceptorInternal medicineInnate immune systemToll-like receptorPulmonary Hypertension Research and TreatmentsEicosanoids and Hypertension PharmacologyInflammatory mediators and NSAID effects