The multifaceted role of aquaporins in physiological cell migration
Ian M. Smith, Kimberly M. Stroka
Abstract
Research has elucidated the water channel protein family of aquaporins (AQPs) as a regulator of many cell migration-related processes, from physical phenomena to biological signaling pathways. The roles that AQPs play in cell migration are both cell type- and isoform-specific; thus, a large swath of information has accumulated as researchers seek to identify the responses across these distinct variables. This review compiles insights into the recent findings linking AQPs to physiological cell migration.
Topics & Concepts
Cell migrationBiologyAquaporinCell typeCell biologyCell fate determinationRegulatorCellAngiogenesisSignal transductionCell signalingTranscription factorGeneticsGeneIon Transport and Channel RegulationNeonatal Respiratory Health ResearchRenal and related cancers