Synthesis, docking and biological evaluation of purine-5-<i>N</i>-isosteresas anti-inflammatory agents
Ahmed M. M. El‐Saghier, Souhaila S. Enaili, Aly Abdou, Amany M. Hamed, Asmaa M. Kadry
Abstract
An operationally simple one-pot three-component synthesis method for a series of diverse purine analogues of [1,2,4]-triazolo[1,3,5]triazine-2-carboxamide derivatives generated in situ via reaction of 2-hydrazinyl- N -(4-sulfamoylphenyl)-2-thioxoacetamide, cyanoguanidine and a variety of aldehydes.
Topics & Concepts
ChemistryPurineCombinatorial chemistryDocking (animal)TriazineOne-pot synthesisStereochemistryOrganic chemistryEnzymeMedicineCatalysisVeterinary medicineSynthesis and Biological EvaluationSynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications