Redox Cyclization of Amides and Sulfonamides with Nitrous Oxide for Direct Synthesis of Heterocycles
Zhencheng Lai, Chaorong Wang, Jiaming Li, Sunliang Cui
Abstract
O serves as a N-atom donor to mediate the intramolecular coupling of lithium species toward heterocycle formation with free external oxidant. This protocol offers a direct synthesis of heterocycles with features of readily available starting materials, simple operation, and a broad substrate scope.
Topics & Concepts
ChemistryMetalationLithium (medication)Combinatorial chemistryNitrous oxideRedoxIntramolecular forceLithium atomSubstrate (aquarium)Organic chemistryIonMedicineEndocrinologyOceanographyGeologyIonizationCoordination Chemistry and OrganometallicsAdvanced Synthetic Organic ChemistryCatalytic Cross-Coupling Reactions