Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healing
Ran Liu, Yu-Rui Jiao, Mei Huang, Nan-Yu Zou, Chen He, Min Huang, Kai-Xuan Chen, Wen-Zhen He, Ling Liu, Yu-Chen Sun, Zhu-Ying Xia, L. Darryl Quarles, Hai-Lin Yang, Wei-Shan Wang, Zhou-Sheng Xiao, Xiang-Hang Luo, Chang-Jun Li
Abstract
PSPCs within the callus can sense mechanical forces through the PC1-TAZ axis, targeting which represents great therapeutic potential for delayed fracture union or nonunion.
Topics & Concepts
Mechanosensitive channelsProgenitor cellCell biologyStem cellBone healingProgenitorCellular differentiationBiologyAnatomyMedicineInternal medicineBiochemistryIon channelGeneReceptorConnective tissue disorders researchGenetic and Kidney Cyst DiseasesBone fractures and treatments