Design, synthesis, and biological evaluation of novel capsaicin-tacrine hybrids as multi-target agents for the treatment of Alzheimer's disease
Juan‐yue Long, Fengxue Qin, Jinchong Luo, Guohui Zhong, Shutong Huang, Lin Jing, Tingzhuang Yi, Jing Liu, Neng Jiang
Topics & Concepts
TacrineButyrylcholinesteraseChemistryAcetylcholinesteraseIC50CholinesterasePharmacologyAchéCapsaicinInhibitory postsynaptic potentialToxicityLead compoundStereochemistryCombinatorial chemistryBiochemistryIn vitroEnzymeReceptorOrganic chemistryNeuroscienceMedicineBiologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsMedicinal Plants and Neuroprotection