Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice
Qi-Qi Liang, Zijian Shi, Tao Yuan, Siyuan Chen, Yaping Li, Hongrui Zhang, Yi-Ping You, Rong Xu, Lihui Xu, Bo Hu, Dong‐Yun Ouyang, Qingbing Zha, Xian‐Hui He
Topics & Concepts
NecroptosisCelastrolRIPK1Programmed cell deathCell biologyPhosphorylationChemistrySignal transductionApoptosisCancer researchBiologyBiochemistryCell death mechanisms and regulationNatural Compounds in Disease TreatmentInflammasome and immune disorders