Mesenchymal Stromal Cell-Based Products: Challenges and Clinical Therapeutic Options
Débora B. Mello, Fernanda Mesquita, Danúbia Silva dos Santos, Karina Dutra Asensi, Marlon Lemos Dias, Antônio Carlos Campos de Carvalho, Regina Coeli dos Santos Goldenberg, Taís Hanae Kasai-Brunswick
Abstract
Mesenchymal stromal cell (MSC)-based advanced therapy medicinal products (ATMPs) are being tried in a vast range of clinical applications. These cells can be isolated from different donor tissues by using several methods, or they can even be derived from induced pluripotent stem cells or embryonic stem cells. However, ATMP heterogeneity may impact product identity and potency, and, consequently, clinical trial outcomes. In this review, we discuss these topics and the need to establish minimal criteria regarding the manufacturing of MSCs so that these innovative therapeutics may be better positioned to contribute to the advancement of regenerative medicine.