An intramolecular hydrogen bond-promoted “green” Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity
Jie Li, Jiu Hong Huang, Jing Ya Wang, Zhi Xu, Zhong Zhu Chen, Jie Lei
Abstract
We report an intramolecular hydrogen bond-promoted Ugi cascade reaction for solvent-free synthesis of 2,5-diketopiperazines. Compounds (±) 5c and (±) 5e displayed potent antitumor activity against acute myeloid leukaemia and prostate cancer cell lines, respectively.
Topics & Concepts
DiketopiperazinesIntramolecular forceChemistryUgi reactionCascadeCombinatorial chemistryHydrogen bondStereochemistryOrganic chemistryIsocyanideMoleculeChromatographySynthesis and Biological EvaluationMulticomponent Synthesis of HeterocyclesSynthesis and biological activity