Anisomycin has the potential to induce human ovarian cancer stem cell ferroptosis by influencing glutathione metabolism and autophagy signal transduction pathways
Ying Xiong, Te Liu, Juan Chen
Abstract
) in peripheral blood exosomes from patients with ovarian cancer, were significantly higher than those of the healthy controls. Therefore, we hypothesized that anisomycin suppressed the expression of members of the glutathione metabolism and autophagy signal transduction pathways by downregulating the expression of ATF4. Moreover, anisomycin has the potential to induce human ovarian cancer stem cell ferroptosis. Overall, we confirmed that anisomycin has multiple targets and many mechanisms of action in inhibiting the activity of OCSCs.
Topics & Concepts
AnisomycinSignal transductionCancer researchBiologyAutophagyCancer cellCell biologyApoptosisCancerBiochemistryKinaseGeneticsFerroptosis and cancer prognosisCancer-related molecular mechanisms researchRNA modifications and cancer