Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice
Yu Zhang, Xiaodong Xi, Hang Yu, Liuyan Yang, Jinzhong Lin, Wen Yang, Junling Liu, Xuemei Fan, Yingjie Xu
Abstract
-transcribed TPO mRNA as a potentially safe therapeutic intervention to stimulate thrombopoiesis.
Topics & Concepts
ThrombopoiesisThrombopoietinMessenger RNAChemistryIn vivoIn vitroGene knockdownMolecular biologyCell biologyBiologyBiochemistryMegakaryocyteGeneHaematopoiesisStem cellBiotechnologyPlatelet Disorders and TreatmentsComplement system in diseasesBlood properties and coagulation