Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults:The Cardiovascular Health Study
Alison E. Fohner, Traci M. Bartz, Russell P. Tracy, Hieab H.H. Adams, Joshua C. Bis, Luc Djoussé, Claudia L. Satizábal, Oscar L. López, Sudha Seshadri, Kenneth J. Mukamal, Lewis H. Kuller, Bruce M. Psaty, W.T. Longstreth
Abstract
Neurofilament light chain (NfL) in blood is a sensitive but nonspecific marker of brain injury. This study sought to evaluate associations between NfL concentration and MRI findings of vascular brain injury in older adults.
Topics & Concepts
MedicineGlial fibrillary acidic proteinHyperintensityInternal medicineCohortWhite matterRelative riskCardiologyMagnetic resonance imagingPathologyConfidence intervalRadiologyImmunohistochemistryFolate and B Vitamins ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments