Insulin blood-brain barrier transport and interactions are greater following exercise in mice
Caitlin Brown, Sarah Pemberton, Alice Babin, Noor Abdulhameed, Cassidy Noonan, Mary Beth Brown, William A. Banks, Elizabeth M. Rhea
Abstract
Central nervous system (CNS) insulin and exercise are beneficial for cognition. CNS insulin resistance is present in Alzheimer's disease. CNS insulin levels are regulated by transport across the blood-brain barrier (BBB). We show that exercise can enhance insulin BBB transport and binding of insulin to the brain's vasculature in mice. There were no changes in serum factors known to alter insulin BBB pharmacokinetics. We conclude exercise could impact cognition through regulation of insulin BBB transport.
Topics & Concepts
InsulinBlood–brain barrierInsulin resistanceInsulin receptorCentral nervous systemInternal medicineEndocrinologyMedicineDiabetes mellitusBiologyNeuroscienceNeuroscience and Neuropharmacology ResearchDrug Transport and Resistance MechanismsBiochemical effects in animals