Cooperation between IRTKS and deubiquitinase OTUD4 enhances the SETDB1-mediated H3K9 trimethylation that promotes tumor metastasis via suppressing E-cadherin expression
Xiaofang Cui, Xueying Shang, Jia Xie, Chen-Yi Xie, Zhanyun Tang, Qing Luo, Chong-Chao Wu, Guangxing Wang, Na Wang, Kunyan He, Lan Wang, Liyu Huang, Bingbing Wan, Robert G. Roeder, Ze‐Guang Han
Topics & Concepts
Deubiquitinating enzymeCDH1Cancer researchChromatinHistoneUbiquitinHistone H3BiologyHistone methyltransferaseCadherinEpithelial–mesenchymal transitionCell biologyMetastasisChemistryMolecular biologyCellGeneticsGeneCancerUbiquitin and proteasome pathwaysEpigenetics and DNA MethylationHistone Deacetylase Inhibitors Research