Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative <i>in vitro</i> pharmacokinetic study of mycophenolate mofetil
Nicolò Milani, Neil Parrott, Daniela Ortiz Franyuti, Patrício Godoy, Aleksandra Galetin, Michael Gertz, Stephen Fowler
Abstract
pharmacokinetic parameters. We propose that similar methodologies may be applied to other multi-organ microphysiological systems used for drug metabolism studies or wherever quantitative knowledge of changing drug concentration with time enables better understanding of biological effect.
Topics & Concepts
MycophenolateProdrugPharmacologyPharmacokineticsDrug metabolismIn vivoMetaboliteGlucuronideMycophenolic acidIn silicoDrugActive metaboliteOrgan-on-a-chipPhysiologically based pharmacokinetic modellingBiologyChemistryBiochemistryMedicineTransplantationInternal medicineGeneMicrofluidicsMaterials scienceNanotechnologyBiotechnology3D Printing in Biomedical ResearchRenal Transplantation Outcomes and TreatmentsPharmacogenetics and Drug Metabolism