Development of a series of flurbiprofen and zaltoprofen platinum(<scp>iv</scp>) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA
Zuojie Li, Linming Li, Wenhuan Zhao, Bin Sun, Zhifang Liu, Min Liu, Jun Han, Zhengping Wang, Dacheng Li, Qingpeng Wang
Abstract
Flurbiprofen platinum( iv ) hybrids exhibit effective antiproliferative and anti-metastasis activities targeting COX-2, PD-L1 and DNA, and exert great potential in boosting T-cell immunity.
Topics & Concepts
MetastasisPlatinumChemistryDNAStereochemistryBiochemistryCatalysisBiologyGeneticsCancerInflammatory mediators and NSAID effectsRadiopharmaceutical Chemistry and ApplicationsMetal complexes synthesis and properties