COVID‐19 chilblain‐like lesion: immunohistochemical demonstration of SARS‐CoV‐2 spike protein in blood vessel endothelium and sweat gland epithelium in a polymerase chain reaction‐negative patient
Carlos Santonja, F. Heras, Lucía Núñez‐Hipólito, Luis Requena
Abstract
A 35‐year‐old woman with no significant previous medical history presented at the Emergency Department of Fundacion Jimenez Diaz Hospital (Madrid, Spain) on April 14th with acral purpuric lesions of three weeks duration. These had started as oedematous, erythematous areas and had appeared coincidentally with fever and coughing, which lasted only two days. There was no history of diarrhoea, ageusia, hyposmia or dyspnea. The patient stated that the skin of her feet acquired a bluish discoloration after standing for some time.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)LesionPathologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)DermatologyEndotheliumEmergency department2019-20 coronavirus outbreakInternal medicineOutbreakDiseasePsychiatryInfectious disease (medical specialty)Dermatological and COVID-19 studiesParvovirus B19 Infection StudiesSkin Diseases and Diabetes