Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
Yuying Liu, Yiliang Fang, Xinfeng Chen, Zhenfeng Wang, Xiaoyu Liang, Tianzhen Zhang, Mengyu Liu, Nannan Zhou, Jiadi Lv, Ke Tang, Jing Xie, Yunfeng Gao, Feiran Cheng, Yabo Zhou, Zhen Zhang, Yu Hu, Xiaohui Zhang, Quanli Gao, Yi Zhang, Bo Huang
Abstract
GSDME-mediated target cell pyroptosis by CAR T cells activates macrophages to release proinflammatory cytokines for CRS.
Topics & Concepts
PyroptosisGranzyme BCell biologyCytotoxic T cellCytokineCD8GranzymeCellCaspase 1Cancer researchInflammasomeChemistryBiologyImmune systemImmunologyPerforinInflammationBiochemistryIn vitroCAR-T cell therapy researchImmune Cell Function and InteractionHematopoietic Stem Cell Transplantation