mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression
Lynnette A. Averill, Christopher L. Averill, Ralitza Gueorguieva, Samar Fouda, Mohamed Sherif, Kyung-Heup Ahn, Mohini Ranganathan, Deepak Cyril D’Souza, Steven M. Southwick, Gerard Sanacora, Ronald S. Duman, John H. Krystal, Chadi G. Abdallah
Topics & Concepts
KetamineAntidepressantmTORC1FluoxetineMajor depressive disorderSuicidal ideationPharmacologyPlaceboMedicinePsychologyInternal medicineAnesthesiaPoison controlPI3K/AKT/mTOR pathwaySuicide preventionChemistrySerotoninHippocampusEmergency medicineBiochemistryAlternative medicineApoptosisPathologyAmygdalaReceptorTreatment of Major DepressionTryptophan and brain disordersBipolar Disorder and Treatment