Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4/NF-κB/NLRP3 signaling in mice
Congqin Li, Xiangyu Xu, Ziwei Wang, Yuyang Wang, Lu Luo, Jing Cheng, Songfeng Chen, Heng-Jian Liu, Qi Wan, Qiang Wang
Abstract
• PTEN, TLR4, NF-κB and NLRP3 are increased in the hippocampus of PSD mice. • PTEN suppression downregulates TLR4, NF-κB and NLRP3 in PSD mouse hippocampus . • Exercise ameliorates PSD via PTEN/TLR4/NF-κB/NLRP3 signaling.
Topics & Concepts
PTENDownregulation and upregulationTLR4NF-κBHippocampusSignal transductionPost-stroke depressionChemistryMedicineCancer researchEndocrinologyPI3K/AKT/mTOR pathwayGeneBiochemistryInflammasome and immune disordersCancer-related molecular mechanisms researchSphingolipid Metabolism and Signaling