A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes
Roman Bychek, Pavel K. Mykhailiuk
Abstract
After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
Topics & Concepts
ScalabilityFlurbiprofenBicyclic moleculeComputer scienceChemistryCombinatorial chemistryComputational chemistryOrganic chemistryPharmacologyMedicineDatabaseFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisSynthesis and Catalytic Reactions