Vitamin B12-Catalyzed Dicarbofunctionalization of Bromoalkenes Under Visible Light Irradiation
Sabina Smoleń, Aleksandra Wincenciuk, Dorota Gryko, Olga Drapała
Abstract
Abstract Vitamin B12 plays a crucial role in enzymatic transformations. This natural compound proved also useful as a catalyst in numerous organic reactions. Commercial availability and lower cost than precious metal complexes, make cobalamin an attractive candidate for a broader use as a benign Co-catalyst. Herein, the vitamin B12-catalyzed dicarbofuntionalization of bromoalkenes with electrophilic olefins is reported leading to substituted pyrrolidines and piperidines in decent yields after only 15 minutes under light irradiation.
Topics & Concepts
ChemistryCobalaminCatalysisVitamin B12ElectrophileIrradiationVisible spectrumOrganic chemistryPhotochemistryCombinatorial chemistryBiochemistryOptoelectronicsNuclear physicsPhysicsPorphyrin Metabolism and DisordersFolate and B Vitamins ResearchPorphyrin and Phthalocyanine Chemistry