Functional Peptides That Target Biomembranes: Design and Modes of Action
Shiroh Futaki
Abstract
Biomembranes are important targets in molecular design. Our laboratory has been exploring the design of functional peptides that modulate membrane barrier function, lipid packing, and structure. Evaluation of the results obtained and analyses of cellular mechanisms have yielded peptides with more refined designs and functions. This review highlights the progress made in our laboratory towards the development of unique peptides that modulate membrane properties.
Topics & Concepts
MembraneChemistryFunction (biology)BiophysicsRational designStructure functionComputational biologyNanotechnologyBiochemistryCell biologyBiologyMaterials sciencePhysicsParticle physicsRNA Interference and Gene DeliveryAntimicrobial Peptides and ActivitiesLipid Membrane Structure and Behavior