2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants
Shashwati Paul, Daniel Adelfinsky, Christophe Salomé, Thomas C. Fessard, M. Kevin Brown
Abstract
-1,3-disubstituted cyclopentanes, common motifs in drugs. The scalable synthesis of these structures was enabled through the use of C-H functionalization logic and cycloaddition reactions.
Topics & Concepts
CyclopentaneBicyclic moleculeChemistryStereochemistryOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions