Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with <i>In Vitro</i> and <i>In Vivo</i> Activity against Dengue and Other Flaviviruses
Steven S. Good, Ashleigh Shannon, Kai Lin, Adel Moussa, Justin G. Julander, Paolo La Colla, Gabriella Collu, Bruno Canard, Jean‐Pierre Sommadossi
Abstract
Every year, millions of people worldwide are infected with dengue virus (DENV), with a significant number developing severe life-threatening disease. There are currently no broadly indicated vaccines or therapeutics available for treatment of DENV infection.
Topics & Concepts
Dengue virusIn vivoVirologyProdrugGuanosineBiologyIn vitroDengue feverViral replicationFlavivirusVirusPharmacologyBiochemistryBiotechnologyMosquito-borne diseases and controlHIV Research and TreatmentMalaria Research and Control