Innate immune response: ally or enemy in cutaneous leishmaniasis?
Héctor Serrano‐Coll, Nora Cardona‐Castro, Ana Pilar Ramos, Alejandro Llanos‐Cuentas
Abstract
Cutaneous leishmaniasis (CL) is an infectious and neglected disease caused by parasites of the genus Leishmania, which produces a wide spectrum of cutaneous manifestations. CL research has shown that the innate immune activity of cells such as neutrophils, natural killers, macrophages, dendritic cells and the complement system are capable of controlling this infection. However, Leishmania can also modulate the immune activity of these cells to promote its own survival and proliferation at the intracellular level. This review discusses the role of the innate immune response in the control and spread of this infection.
Topics & Concepts
Innate immune systemImmune systemCutaneous leishmaniasisImmunologyBiologyLeishmaniaLeishmaniasisVirologyMicrobiologyParasite hostingComputer scienceWorld Wide WebResearch on Leishmaniasis StudiesUrticaria and Related ConditionsParasites and Host Interactions