An antibacterial and healing-promoting collagen fibril constructed by the simultaneous strategy of fibril reconstitution and ε-polylysine anchoring for infected wound repair
Xiaoxia Zhang, Changkai Yang, Xin Guo, Chun Yang, Guoying Li
Abstract
-infected dermal wound model further demonstrated that the reconstituted antibacterial collagen fibril visibly promoted re-epithelialization, new collagen deposition, and angiogenesis by down-regulating the inflammatory-relative gene IL-6 and up-regulating the relative activity factor expression of CD31, achieving accelerated infected wound healing with 61.89% ± 3.96% wound closure on postoperative day 7 and full closure on day 14.
Topics & Concepts
FibrillogenesisFibrilWound healingChemistryAntibacterial activityGranulation tissueCollagen fibrilPolylysineCell biologyBiophysicsBiochemistrySurgeryMedicineBiologyBacteriaGeneticsWound Healing and TreatmentsAntimicrobial agents and applicationsPeriodontal Regeneration and Treatments