The PCOS–NAFLD Multidisease Phenotype Occurred in Medaka Fish Four Generations after the Removal of Bisphenol A Exposure
Sourav Chakraborty, Santosh Anand, Seraiah T. Coe, Beh Reh, Ramji Kumar Bhandari
Abstract
signaling in the ovary. The present results suggest that ancestral BPA exposure can lead to PCOS phenotypes in the subsequent unexposed generations and warrant further investigations into potential health risks in future generations caused by initial exposure to EDCs.
Topics & Concepts
Polycystic ovaryBiologyPhenotypeOvaryTranscriptomeMetabolomicsEndocrine disruptorEndocrinologyInternal medicineNonalcoholic fatty liver diseaseSteatosisPhysiologyGeneticsFatty liverEndocrine systemDiseaseBioinformaticsGeneHormoneMedicineInsulinInsulin resistanceGene expressionEffects and risks of endocrine disrupting chemicalsMetabolomics and Mass Spectrometry StudiesAdipose Tissue and Metabolism