Ferroptosis in cancer (Review)
Liyi Zeng, Xiaohui Liu, Chengjie Geng, Xuejuan Gao, Langxia Liu
Abstract
Ferroptosis is a type of programmed cell death depending on iron and reactive oxygen species. This unique cell death process has attracted a great deal of attention in the field of cancer research over the past decade. Research on the association of ferroptosis signal pathways and cancer development indicated that targeting ferroptosis has great potential for cancer therapy. In the present study, the latest research progress of ferroptosis was reviewed, focusing on the relationship between ferroptosis and the development of cancer, in order to further promote the clinical application of ferroptosis in cancer.
Topics & Concepts
CancerOncogeneCell cycleCancer cellCancer researchProgrammed cell deathApoptosisBiologyGeneticsFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer