Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation
Gloria Biechele, Tanja Blume, Maximilian Deußing, Benedikt Zott, Yuan Shi, Xianyuan Xiang, Nicolai Franzmeier, Gernot Kleinberger, Finn Peters, Katharina Ochs, Carola Focke, Christian Sacher, Karin Wind, Claudio Schmidt, Simon Lindner, Franz‐Josef Gildehaus, Florian Eckenweber, Leonie Beyer, Barbara von Ungern‐Sternberg, Peter Bartenstein, Karlheinz Baumann, Mario M. Dorostkar, Axel Rominger, Paul Cumming, Michael Willem, Helmuth Adelsberger, Jochen Herms, Matthias Brendel
Abstract
TSPO-PET represents a sensitive biomarker for monitoring of immunomodulation and closely reflects activated microglia. Sex and pre-therapeutic assessment of baseline microglial activation predict individual immunomodulation effects and may serve for responder stratification.