A Systematic Review on the Antimicrobial Activity of Andrographolide
Gayus Sale Dafur, Aiza Harun, Tuan Noorkorina Tuan Kub, Ruzilawati Abu Bakar, Azian Harun
Abstract
. Nonetheless, variations in its efficacy across different microorganisms were observed. The quality assessment revealed low bias risk in 11 out of 16 studies (78.57% to 92.86%), while the remaining five had medium bias risk (57.14% to 64.29%), indicating an overall acceptable quality of the studies. Information on andrographolide's potential and effectiveness across various microorganisms is crucial. Therefore, the purpose of this review was to synthesize the existing data on andrographolide's antimicrobial activity and assess its potential in combating antimicrobial resistance. This review highlights the need for further research on andrographolide's antifungal activity, mechanisms of action, clinical safety, toxicity, and potential applications in antimicrobial resistance strategies.