Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy
Mithunah Krishnamoorthy, Lara Gerhardt, Saman Maleki Vareki
Abstract
The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.
Topics & Concepts
Myeloid-derived Suppressor CellImmunotherapyCancer immunotherapyImmunologySuppressorMyeloid cellsMyeloidCancerImmunityMedicineImmune systemCancer researchInflammationInternal medicineImmune cells in cancerCancer Immunotherapy and BiomarkersInflammatory Biomarkers in Disease Prognosis