Harnessing mRNA-lipid nanoparticles as innovative therapies for autoimmune diseases
Rose Razavi, Michael Kegel, Jenna Muscat-Rivera, Drew Weissman, Jilian R. Melamed
Abstract
chimeric antigen T cell therapies. To successfully advance this promising class of therapies to the clinic, key challenges must be addressed, such as mitigating unwanted inflammation caused by LNPs, overcoming biological barriers to delivery, and ensuring the long-term safety of mRNA-LNPs specifically in autoimmune contexts. Through their modular design, flexible application, and potential for cost-effective production, mRNA-LNP therapies offer exciting clinical potential to transform the management of autoimmune diseases.
Topics & Concepts
MedicineNanotechnologyComputational biologyBiologyMaterials scienceRNA Interference and Gene DeliveryMonoclonal and Polyclonal Antibodies ResearchViral Infections and Immunology Research