IR820 functionalized melanin nanoplates for dual-modal imaging and photothermal tumor eradication
Botao Qu, Xiaomin Zhang, Yahong Han, Xiaoyang Peng, Jinghua Sun, Ruiping Zhang
Abstract
investigations reveal that the MPI NPs afford a potent PTT effect and ideal resistance to photobleaching. After intravenous injection, the MPI NPs display effective PTT tumor eradication in a Hep-2 tumor bearing mouse model with excellent dual NIR-I fluorescence/photoacoustic imaging guided phototherapy. Hence, our work shows the potential of MPI NPs as nano-theranostics for biomedical application to laryngocarcinoma.
Topics & Concepts
Photothermal therapyIn vivoMelaninPhotobleachingFluorescenceFluorescence-lifetime imaging microscopyNanotechnologyBiophysicsMaterials scienceNanomedicineChemistryBiomedical engineeringNanoparticleOpticsMedicineBiochemistryBiologyBiotechnologyPhysicsNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingExtracellular vesicles in disease