Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer
Wen‐Yun Tan, Yi Lu, Jingfeng Zhao, Wen Chen, Hongbin Zhang
Abstract
The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.
Topics & Concepts
ChemistryPrimary (astronomy)Alcohol oxidationAlcoholCarboxylic acidOrganic chemistryAldehydeFunctional groupReaction conditionsCombinatorial chemistryCatalysisPhysicsPolymerAstronomyOxidative Organic Chemistry ReactionsSynthesis and Catalytic ReactionsChemical Synthesis and Reactions