Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge
Fien A. von Meijenfeldt, Sebastian Havervall, Jelle Adelmeijer, Annika Lundström, Maria Magnusson, Nigel Mackman, Charlotte Thålin, Ton Lisman
Abstract
2] 5] Moreover, we have recently shown that the prothrombotic changes found in COVID-19 patients shortly after admission are associated with disease severity and mortality. 10 These data align with the hypothesis that the prothrombotic changes in COVID-19 patients contribute to disease progression, potentially by facilitating pulmonary (micro)thrombosis. 4] We hypothesize that the post-COVID-19 syndrome may involve sustained intrapulmonary activation of coagulation, perhaps driven by residual pulmonary microvascular injury, with ongoing pulmonary microthrombosis as a consequence. To the best of our knowledge, the hemostatic status of COVID-19 patients after hospital discharge has not yet been assessed. Therefore, we studied the hemostatic status of patients with a resolved COVID-19 infection. We have previously reported the hemostatic status of a cohort during hospital admission and these patients were a subset. n this study, we report the hemostatic status of these patients at 4 months after hospital discharge.