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(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression

Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Megumi Naito, Takumi Yamaguchi, Lu Chen, Atsushi Kasai, Kaoru Seiriki, Takanobu Nakazawa, Shinsaku Nakagawa, Kenji Hashimoto, Hitoshi Hashimoto, Yukio Ago

2020Pharmacology Biochemistry and Behavior67 citationsDOI

Topics & Concepts

CorticosteroneBehavioural despair testAnhedoniaAntidepressantKetamineAntagonistAnimal models of depressionEndocrinologyInternal medicinePharmacologyTail suspension testPsychologyReceptorMedicineHippocampusPsychiatryHormoneDopamineTreatment of Major DepressionTryptophan and brain disordersTea Polyphenols and Effects
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression | Litcius